In the last 2 decades, a medicine began to emerge as a surprising treatment for mood disorders. It was developed and approved for anaesthesia around 1970. Over 25 years later… it began to show its hidden ability. The power to relieve depression and other mood disorders in a most dynamic way. Disorders like PTSD, bipolar depression, postpartum depression, generalised & social anxiety, and even eating disorders respond to this extraordinary treatment modality. And perhaps the most remarkable of all, it can even erase suicidal thinking in a few short hours.
Mental Health researchers tested low doses of this dissociative anaesthetic with trepidation 20 years ago. Then each study built upon the last. Their work revealed more insights about what actually causes depression, and how to treat it effectively. Never before has one medicine helped relieve symptoms of psychological distress in such a wide variety of people.
It works in multiple areas and systems of the brain. It improves the function of mechanisms that have been impaired by the stress of depression and anxiety. It helps the G proteins that pile up on lipid rafts in the cell membrane slide to off. This equips them so they can do their job enhancing signal transmission.
It also turns on the mRNA switch which in turn flips on DNA to build up brain-derived-neurotrophic-factor (BDNF). BDNF then causes synapse connections between neurons to proliferate in turbo mode, transforming and replenishing the connections between brain cells all around the brain, lighting it up with information, cognition, creativity, and insight.
There’s more that it accomplishes, like tamping down the cell bursting in the lateral habenula so you can experience the reward of pleasant moments. We don’t know what researchers haven’t discovered yet, but we look forward to hearing what’s next.
The results of treatment are transformative. Those who have been weighed down under a heavy blanket of lethargic apathy and despair typically find they feel better and better after each treatment. They often find they have the energy and motivation to dive into tasks they couldn’t face in recent memory.
Patients with treatment-resistant conditions respond more compared to any other medicine available. It may sound odd, but the patients it helps the most are those who suffer from severe disorders. With continued research, neuroscience researchers and clinicians are learning new methods of administration that can help more and more patients enjoy a rapid and robust response.
As a result, these individuals enjoy renewed hope. They express amazement at their energy for life and work, and an overall transformation in what they enjoy and are able to accomplish. They report a more balanced and joyful outlook, and the desire to rebuild and strengthen their relationships.
One of the most exciting recent breakthroughs from research funded by the National Institute of Mental Health (NIMH) is the development of a fast-acting nasal spray for treatment-resistant depression. This treatment is bringing new hope to people and families affected by major depression.
K1 Revival Clinic does not endorse any specific product. External links are observations, judgements and opinions of clinicians and researchers regarding new indications for a well established widely used dissociative anaesthetic. As a registered anaesthetic analgesic since 1970 it has been administered safely to billions of patients in controlled clinical settings and is on the World Health Organisations list of essential medicines. Please ask your doctor about the paradigm shift in the treatment of depression.
Created for CONTINUING MEDICAL EDUCATION 2020